Do you have to get worse before you get better?

Many treatments for Lyme Disease may trigger the natural bodily response known as the Herxheimer reaction. Frequently seen during antibiotic or antimicrobial treatments, the “Herx” reaction occurs as damaging bacteria are destroyed.

When harmful microorganisms and bacteria die, they release endotoxins (which were previously contained within the living bacteria) into the bloodstream. This allows the toxins to be flushed from the body, but a rapid “die-off” can trigger an acute immune response resulting in inflammation, worsening of current symptoms and the development of new symptoms. Pain, fatigue, cognitive issues and brain fog are common.


A Herx reaction usually means that the treatment is working effectively and should be continued.

Common symptoms that develop or worsen due to a Herxheimer response include:

  • Bloating
  • Brain Fog
  • Chills
  • Cold Sweats
  • Constipation
  • Cramps
  • Diarrhea
  • Fatigue
  • Fever
  • Headaches
  • Irritability
  • Joint Pain
  • Lethargy
  • Muscle Pain
  • Nausea
  • Skin Irritation
  • Sore Throat

Symptoms may begin within hours of treatment or develop days later. The severity and duration of the Herxheimer reaction can depend on the condition being treated, the treatment method and the patient’s overall health. A Herx reaction usually means that the treatment is working effectively and should be continued.

But do you have to get worse before you get better? Some patients avoid, delay or discontinue treatment due to Herxheimer concerns, but there are some strategies that may help reduce the severity and/or duration of reactions –  and improve the everyday symptoms of Lyme Disease as well. MANAGING LYME DISEASE, from the International Lyme and Associated Diseases Society, has many suggestions.


At ROC02 Labs, we provide treatments that bolster the immune system, facilitate detoxification, and have been shown to benefit Lyme Disease patients. When added to traditional medical care, therapies including IV Nutrition, Hyperbaric Oxygen (HBOT), Hyperthermic Ozone and Carbonic Acid Transdermal Technology (HOCATT) and Infrared Sauna can relieve symptoms, improve quality of life and minimize Herxheimer reactions. Can we help you? Give us a call.

Download a copy of our “7 Things to Know about Lyme Disease